A PhD position is available for four years for a project in the area of biocatalysis, bio-organic chemistry and biotechnology. The project deals with the asymmetric synthesis of chiral amines and amino alcohols starting from renewable building blocks or waste, and through cascade reactions. The position is immediately available and work can start as soon as possible.What are you going to do
The project comprises the following tasks: (i) the engineering of novel enzymes to improve existing catalytic activity, or expand substrate scope or tune chemical selectivities; (ii) the further utilisation of these enzymes into multi-enzymatic reactions aimed at the conversion of renewable building blocks into chiral amines and amino alcohols; (iii) the testing of the cascade reactions through the co-expression of the enzymes in a microbial strain and biotransformations in vivo, or through the use of immobilised enzymes in flow systems; (iv) write periodic scientific reports, manuscripts and a PhD thesis.
This project will be developed in synergy with already existing projects in the biocatalysis group, dealing with enzymatic degradation of renewable starting material or synthetic polymers and the asymmetric synthesis of amines.What do we require
Candidates must hold a Master’s diploma in chemistry or biotechnology or a cognate discipline. The ideal PhD candidate should have theoretical knowledge and some hands-on experience in one or more of the following sub-disciplines: - biocatalyis and biotransformations; - enzyme engineering (incl. computational/structural analysis of proteins); - synthetic organic chemistry; - standard cloning techniques of molecular biology; - analysis of biochemical reaction via GC/HPLC.
The ability to collaborate and adapt in an international team is of utmost importance, and candidates must possess good communication skills in oral and written English.Our offer
A temporary contract for 38 hours per week, preferably starting on 1 November or 1 December 2021, for the duration of four years (the initial contract will be for a period of 18 months and after satisfactory evaluation it will be extended for a total duration of four years). This should lead to a dissertation (PhD thesis). We will draft an educational plan that includes attendance of courses and (international) meetings. We also expect you to assist in teaching undergraduates and master students.
The salary, depending on relevant experience before the beginning of the employment contract, will be €2,434 to €3,111 (scale P) gross per month, based on a fulltime contract (38 hours a week). This is exclusive 8 % holiday allowance and 8.3% end-of-year bonus. A favourable tax agreement, the ‘30% ruling’, may apply to non-Dutch applicants. The Collective Labour Agreement of Dutch Universities is applicable.
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