We invite highly motivated candidates with experience in cell culture and antibody production to apply.

A healthy immune system clears microbes without damaging the body. For this purpose, immune cells are regulated by inhibitory receptors that serve as a break on activation. These receptors can also prevent efficient clearing of tumour cells. This project is focused on a few key newly identified targets for which we will develop antibodies in collaboration with UMAB. To make the first steps towards clinical application, you will screen antibodies for binding to cell-expressed receptors. You will also test their ability to block these receptors in functional assays.

You will part of the Inhibitory Receptor Lab that is led by Dr. Michiel van der Vlist and Prof. Linde Meyaard. The Inhibitory Receptor Lab is situated in Center for Translational Immunology in the UMC Utrecht and is part of the Oncode Institute. At the Center for Translational Immunology, approximately 200 people study immune responses in all their facets. We have a state-of-the-art flow cytometry facility, imaging facility, protein facility and the antibody generation facility U-MAB, all set up to facilitate the best transitional research possible. 

In the Inhibitory Receptor Lab a dynamic and international team studies immune inhibitory receptors in health and disease. Our basic research line focuses on identification and characterization of inhibitory receptors, their ligands and mechanism of action. We have a strong translational focus to apply our knowledge in the clinic to cure patients. To foster this goal, research in our group covers the complete spectrum from academic basic to translational research, as well as public-private collaborative research. We strive for a diverse and inclusive working environment where we are kind to the person, but though on the data.  
Please visit our website: www.inhibitoryreceptorlab.nl for more information about our team.

Required skills:

• Intrinsic interest and motivation for early-stage therapeutic development.
• Experience in cell culture and flow cytometry-based assays.

Preferred skills:

• Affinity with immunology.
• Experience with assay design and trouble shooting.

• A salary between €2861 and €4052 gross per month (salary scale 7M), based on full-time employment (36 hours).
• Salary increase of 4% per May 2024.
• Year-end bonus of 8.3% and holiday allowance of 8%. 
• Pension insurance with ABP. We take care of approximately 70% of the monthly contribution.
• Access to a variety of online courses through GoodHabitz.