We are looking for an enthusiastic and ambitious post-doc candidate in the Laboratory of Cellular senescence and age-related pathologies, headed by prof. dr. Marco Demaria, to work on projects related to senolytic interventions in murine disease models.
Cellular senescence is a complex tumor-suppressive mechanism induced by many different stresses. Senescent cells are characterized by growth arrest, changes in morphology and gene expression, and the secretion of inflammatory cytokines, proteases and other molecules that can alter the tissue microenvironment (a phenomenon termed the senescence-associated secretory phenotype or SASP). For an unknown mechanism, senescent cells increase with age, and are evident at sites of numerous age-related pathologies and pre-cancerous lesions. Recent results show that life-long elimination of senescent cells can prevent the development of certain age-related pathologies in a mouse model of segmental accelerated aging, strongly supporting the idea that senescent cells can be deleterious.
The Demaria lab is interested to dissect the molecular phenotypes of cellular senescence induced by different stimuli, and to characterize how they can promote age-related dysfunctions.
The proposed project aims to determine the potential effect of senolytic interventions in reducing onset and progression of age-related dysfunctions. Major focus will be on characterizing renal dysfunctions in the context of tissue damage and on evaluating frailty during natural aging. The project will use mainly mouse models with the support of cellular systems for the understanding of molecular mechanisms.
The European Research Institute for the Biology of Aging (ERIBA) is a research institute within the University Medical Center Groningen (UMCG). ERIBA aims to discover molecular mechanisms of ageing that can be used as targets to prevent or delay age-related diseases. Our research teams are working with different model systems and technology platforms and share their knowledge and expertise to accelerate discoveries. Furthermore, we heavily invest in Systems Biology to integrate our findings in the various mechanisms of ageing that have been proposed. ERIBA is housed in a brand new building and part of the central UMCG campus in central Groningen, a vibrant student town (with over 25,000 students) in the northern Netherlands. PhD students are enrolled in the Graduate School of Medical Sciences of the University of Groningen.
The postdoc will be part of a young and enthusiastic research group and should have the following requirements:
- required education/skills: PhD in Molecular/Cellular/Medical Biology;
- experience in a wide variety of molecular and cellular biology techniques (e.g. qPCR, FACS, Western blots, histology);
- experience working with mouse models;
- successful PhD trajectory with at least one first authorship;
- developed skills in R programming and large datasets analysis is a plus;
- should be enthusiastic, ambitious, and organized;
- collaborative, communication and networking skills are mandatory.
The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.
The employment basis is a temporary contract for one year with a possible extension with an extra year. Your salary will be a maximum of € 4.707,- gross per month (scale 10), depending on your qualifications and relevant experience, based on a full-time appointment.
In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus.
The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).
It concerns a full time appointment (36 h/week) for a period of two years. After one year, the performance of the candidate will be evaluated to decide whether there is sufficient progress to extend for a second year. Additional extensions are likely and will be discussed in due time.
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prof. dr. Marco Demaria
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Please use the the digital application form at the bottom of this page - only these will be processed.
You can apply until 22 May 2022.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.
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