Join the transplantation lab and contribute to impactful research in organoids.
What happens when your organs talk to each other and the immune system listens? In this internship, you'll dive into the fascinating world of liver-kidney immune crosstalk, using cutting-edge organoid models and iPSC-derived macrophages to mimic acute kidney injury in a dish. You'll help uncover how immune cells mediate communication between organs during injury, potentially revealing new targets to prevent or treat kidney damage. Topics include:
- How do iPSC-derived macrophages respond to signals from injured liver and kidney organoids?
- Which activation and differentiation markers define macrophage responses during liver-kidney crosstalk?
- How do immune signals from one organ influence injury or repair mechanisms in the other?
Main responsibilities:
- Set up and maintain co-cultures of iPSC-derived macrophages with liver and kidney organoids to model organ-organ immune interactions.
- Perform Immunohistochemistry, flow cytometry (FACS), qPCR, and cytotoxicity assays to assess macrophage-organ injury crosstalk, and immune cell activation.
- Process and analyze experimental data using relevant software tools.
- Discuss findings and present results in lab meetings and reports.