ProQR Therapeutics is a NASDAQ‑listed biotechnology company headquartered in Leiden, Netherlands, with an office in Cambridge, Massachusetts, USA. Our proprietary Axiomer™ RNA editing technology platform edits specific single nucleotides in RNA using the cell’s own editing machinery (ADAR) to repair G‑to‑A mutations, modulate protein function and enable protective mutation functions. By harnessing the power of RNA editing, we aim to create a world where genetics inform your health – but never limit it.
RoleWe are looking for a senior Principal Scientist Liver to lead our liver portfolio. As Principal Scientist Liver you will provide scientific leadership for liver programs, drive discovery and development of novel RNA‑based drug candidates for chronic liver diseases, shape scientific strategy, guide project teams in a matrix environment (without direct line management), and collaborate closely with internal and external partners to advance our liver pipeline and platform.
Key Responsibilities- Define and drive the scientific strategy for liver programs within the Axiomer platform.
- Provide expert input into target selection, disease biology, and translational strategy for chronic and genetic liver diseases.
- Lead efforts to elucidate mechanisms of action for targets and candidates using state‑of‑the‑art tools and analytics.
- Oversee design and interpretation of in‑vitro and in‑vivo studies relevant to liver biology and pathology.
- Support definition and assay implementation of target‑related biomarkers.
- Interpret complex datasets (omics, translational data, pharmacology), including correlation and predictive modelling, and make data‑driven decisions.
- Collaborate with internal teams (R&D, Clinical Operations) and external partners (CROs, academic groups) to align research plans and deliverables.
- Proactively identify scientific and operational risks, propose mitigation strategies, and drive resolution.
- Identify and evaluate new scientific and technological opportunities in nucleic acid therapeutics and delivery platforms for liver.
- Serve as a scientific mentor and role model within project teams, fostering high‑quality science and effective teamwork.
- Communicate complex concepts clearly to both scientific and non‑scientific stakeholders, including senior leadership.
- PhD in a relevant field, such as Liver Biology, and at least 10 years of post‑graduate experience in pharmaceutical/biotech R&D or academic research dedicated to liver diseases.
- Deep understanding of liver biology and complex biological systems.
- Proven track record in liver disease drug discovery, ideally including genetic liver diseases.
- Experience with oligonucleotide and/or RNA/base editing therapeutics and their liver‑targeted delivery technologies is a strong plus.
- Demonstrated experience in designing and leading in‑vivo and in‑vitro studies in liver disease models.
- Experience supervising, mentoring teams or project groups in a matrix environment.
- Solid understanding of in‑silico and computational approaches supporting drug discovery and development.
- Strategic thinker, comfortable working in a fast‑paced, dynamic biotech environment.
- Flexible, proactive, solutions‑oriented mindset.
- Excellent communication skills in English, both written and verbal.
- Self‑starter, collaborative team player.
We are committed to ensuring that no employee, candidate, or job applicant receives less favourable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage or civil partnership status. We foster an inclusive culture where all differences are recognized and valued.
- Annual performance bonus
- Stock options
- Premium‑free pension plan
- Commuting allowance
- Unlimited snacks and drinks
- Employee events (boot camp, Coffee & Collaboration Café and other social events)
€85000 - €120000 monthly