Bayer

Leider ist dieser Job nicht mehr aktiv

Originele vacaturetekst

Master Student Intern in Pharmacokinetic Modeling & Simulation (m/f/d)

At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’. There are so many reasons to join us. If you’re hungry to build a varied and meaningful career in a community of brilliant and diverse minds to make a real difference, there’s only one choice.

Master Student Intern in Pharmacokinetic Modeling & Simulation (m/f/d)

We are looking for a Master Student Intern (m/f/d) who is interested in collaboration with University Hospital Aachen, Institute for Systems medicine with Focus on Organ Interaction on the topic: "Modeling of Oral Bioavailability of beyond Rule of Five Compounds"


Lipinkski’s rule or rule of five (Ro5) was formulated in the late 1990s to qualitatively assess the likelihood of oral bioavailability of synthetic molecules. The majority of the currently marketed drugs comply with this rule. However, pharmaceutical industry’s quest to address unmet medical needs in complex diseases requires modulation of novel targets with highly innovative treatment modalities, that are beyond classical small molecules and therefore beyond the chemical space outlined by the Ro5 (beyond Ro5: bRo5).


YOUR TASKS AND EDUCATIONAL OBJECTIVES


This master project aims to assess a fitness of the drug metabolism and pharmacokinetics (DMPK) in vitro screening cascade for optimization/selection of bRo5 compounds with oral bioavailability. With this goal 50 bRo5 compounds already studied in the clinical trials were already selected. Literature databases were mined to extract in vivo pharmacokinetic properties of these substances. These substances were also profiled in selected DMPK in vitro assays. The goal of your master project will be to:

  • Establish in vitro/in vivo correlations for the bRo5 compounds
  • Compare it with in vitro/in vivo correlations for the Ro5 compounds
  • Investigate formulation effects on oral bioavailability
  • Integrate diverse in vitro data into a PBPK model to improve in vivo PK prediction


WHO YOU ARE

  • Currently in the end of your master studies in natural science or bio science
  • Have a quantitative mindset and experience with modelling and/or statistical analysis in a scripting environment (R, Matlab, etc.)
  • Interested and preferably experienced in physiologically based pharmacokinetic modelling
  • A highly motivated individual with an interest in drug discovery and development, in particular, drug metabolism and pharmacokinetics
  • Willing to learn and enjoy working in an interdisciplinary team
  • A good command of spoken and written English

Please apply online submitting a cover letter, your CV, certificates, proof of enrollment, current transcript of records as well as internship guidelines of your university. Please indicate your earliest start date and timeframe in your application.

Bayer welcomes applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

Location: ​​ ​ Wuppertal ​

​​Division: ​ Pharmaceuticals​

Reference Code: 507862​

Art des Stellenangebotes:
Intern

Fähigkeiten

  • Es ist kein Abschluss erforderlich