Proclinical is working alongside an internationally recognised drug discovery organisation who are seeking an experienced Associate Principal Scientist to provide scientific leadership across innovative preclinical discovery programmes focused on kidney disease, nephrology, chronic kidney disease, acute kidney injury, renal fibrosis and progressive renal disorders.
This is a senior scientific leadership opportunity for an experienced pharmacologist with expertise in renal disease biology and translational drug discovery. You will play a key role in advancing novel therapeutics from target validation through candidate selection while working closely with biotechnology and pharmaceutical partners developing next-generation treatments for kidney disease.
The Opportunity
Working within multidisciplinary drug discovery teams, you will be responsible for the design, delivery, and interpretation of pharmacology studies supporting programmes across:
Chronic Kidney Disease (CKD)
Acute Kidney Injury (AKI)
Diabetic Kidney Disease (DKD)
Diabetic Nephropathy
Renal Fibrosis
Glomerular Disease
Podocyte Biology
Proteinuria
Albuminuria
Tubulointerstitial Fibrosis
Kidney Inflammation
Fibrotic Kidney Disorders
Metabolic-Renal Disease
Cardio-Renal DiseaseYou will contribute to target validation, mechanism-of-action studies, translational biomarker strategies and efficacy assessment, supporting progression of novel therapeutics into development.
Key Responsibilities:
Lead and scientifically direct in vivo pharmacology programmes focused on renal and nephrology indications
Design and oversee studies utilising relevant disease models of:
CKD
AKI
Renal Fibrosis
Diabetic Kidney Disease (DKD)
Proteinuric Kidney Disease
Glomerulonephritis
Nephropathy
Kidney Inflammation
Progressive Renal Disease
Drive translational pharmacology strategies linking preclinical findings to clinical outcomes
Support target validation and mechanism-of-action studies across pathways implicated in:
Fibrosis
Inflammation
Immune-Mediated Kidney Disease
Metabolic Dysfunction
Tissue Remodelling
Renal Injury and Repair
Analyse and interpret efficacy, pharmacodynamic and biomarker data to guide programme decisions
Collaborate with medicinal chemistry, DMPK, translational science, biomarker and safety teams
Present scientific recommendations and project updates to external biotech and pharmaceutical clients
Mentor scientists and contribute to the development of innovative in vivo and translational capabilities
About You
Essential Experience
PhD in Pharmacology, Physiology, Nephrology, Biomedical Sciences or related discipline, or equivalent industry experience
Significant experience in in vivo pharmacology within pharmaceutical, biotechnology or CRO-based drug discovery environments
Strong expertise in renal disease biology and nephrology research
Experience working within one or more of the following areas:
Chronic Kidney Disease (CKD)
Acute Kidney Injury (AKI)
Diabetic Kidney Disease (DKD)
Diabetic Nephropathy
Renal Fibrosis
Kidney Inflammation
Glomerular Disease
Proteinuria
Albuminuria
Podocyte Dysfunction
Tubular Injury
Fibrotic Disorders
Proven ability to design, interpret and lead complex preclinical pharmacology studies
Experience influencing scientific strategy and programme progression decisions
Knowledge of UK regulations governing in vivo research
Excellent communication and stakeholder engagement skills Highly Desirable
Expertise in translational nephrology
Biomarker identification and validation
Renal functional endpoints including:
eGFR
Albumin-Creatinine Ratio (ACR)
Urine Protein Biomarkers
Renal Histopathology
Experience with pathways including:
TGF-? Signalling
Fibrotic Pathways
Inflammatory Cytokine Signalling
Complement Biology
Kidney Repair Mechanisms
Metabolic-Renal Pathways
Client-facing scientific leadership within a CRO environment
Project or line management experience
Why Apply?
Lead cutting-edge nephrology and renal drug discovery programmes
Work on novel therapies targeting CKD, AKI, renal fibrosis and progressive kidney disease
Influence strategic scientific decisions across multiple programmes
Collaborate with leading biotech and pharmaceutical organisations
Join a highly collaborative, research-driven environment with strong opportunities for scientific and leadership progression
If you are having difficulty in applying or if you have any questions, please contact Neil Walton at (url removed).
If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page.
Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.
By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data
Salary description
£50000.00 - £500000.00 per year