Barrington James is supporting an emerging biotechnology company that is looking to appoint a senior preclinical development leader to support the progression of antibody-based therapeutic programmes towards clinical development.
This is a hands-on strategic role for someone with strong in vivo pharmacology and preclinical development experience, who can help shape the right study strategy from early proof-of-concept through IND/CTA-enabling activity.
Key Responsibilities
- Lead preclinical strategy across early-stage antibody therapeutic programmes.
- Design, oversee and interpret in vivo pharmacology, PK/PD, toxicology and safety studies.
- Provide input on disease model selection, species relevance, endpoints, dose rationale and translational value
- Manage outsourced studies with CROs, consultants and external study directors
- Interpret complex in vivo and toxicology data, identifying key risks, limitations and next steps
- Work cross-functionally with discovery, translational, CMC, regulatory and clinical stakeholders
- Support candidate selection and IND/CTA-enabling documentation
Experience Required
- Strong background in in vivo pharmacology, preclinical development or nonclinical strategy
- Experience progressing antibody-based, biologic or complex therapeutic programmes towards IND/CTA or early clinical development
- Strong understanding of animal model selection, pharmacology study design, PK/PD, toxicology and translational interpretation
- Experience managing external CROs and outsourced in vivo studies
- Ability to challenge study design, interpret complex data and translate findings into clear development recommendations.