Senior Scientist - DMPK

Senior Scientist (DMPK)
12-month FTC
Cambridge
A leading biotech organisation is seeking a Senior Scientist with DMPK expertise to support oncology-focused discovery programs. You will develop fit-for-purpose DMPK strategies, generate and interpret ADME/PK data, and work closely with internal project teams and external CRO partners to drive decision-making across project stages.
Key Responsibilities

Develop and evolve an appropriate DMPK screening cascade aligned to project stage and objectives.
Design, execute and interpret in vitro ADME assays, communicating results clearly to project team members.
Oversee CRO activities including compound submissions, experiment tracking, and timely communication of data updates.
Prepare and maintain slide decks and documentation summarising CRO outputs and project progress; manage purchase orders and invoicing related to CRO work.
Maintain accurate, complete and up-to-date electronic laboratory notebooks in line with internal standards.
Perform LC-MS/MS analyses for small and large molecules, including routine maintenance and basic troubleshooting.Key Requirements

PhD or BSc/MSc with relevant experience in a life sciences discipline, plus industrial drug discovery experience.
Practical knowledge of in vitro ADME assays including microsomal stability, hepatocyte stability, protein binding and permeability.
Experience using Phoenix WinNonlin.
Knowledge and prior experience of metabolite identification.
Strong time management, excellent written and verbal communication skills, and the ability to build effective relationships with internal and external partners.
Experience advancing discovery programs from Lead Optimisation (LO) through candidate selection.
Knowledge of PK-PD and/or PBPK modelling and human dose prediction.
Practical experience in bioanalysis by LC-MS/MS.
Experience with MassLynx and/or UNIFI.Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy