The project is conducted in collaboration with the Group of Prof. Sven Rottenberg (University of Bern) and involves leading computational method development and integrative analyses of large-scale transcriptomic, spatial and functional-genomic datasets from experimental models, patient tumours and public resources to derive biomarkers of ECHDC2-linked metabolic rewiring and uncover targetable vulnerabilities associated with resistance to radiotherapy, chemotherapy and radioligand therapy. The postdoctoral researcher will take a leading role in developing and applying computational workflows for bulk and single-cell RNA-seq, spatial profiling and functional-genomic data; integrating project-generated data with clinically annotated cohorts and public resources; and deriving robust ECHDC2-associated biomarkers, transcriptional signatures and prioritised targetable vulnerabilities for downstream validation. The postdoctoral researcher is expected to drive the computational strategy of the project, contribute to the supervision of junior researchers, coordinate analyses with collaborators, and disseminate the findings through publications, poster presentations and talks within the UMCG as well as at national and international meetings.
The postdoctoral researcher will be part of an enthusiastic and multidisciplinary research group and should meet the following requirements.
- A PhD degree in bioinformatics, computational biology, data science, systems biology, biomedical sciences, artificial intelligence, or a related field;
- Strong experience with transcriptomic or other omics data analysis, statistics, and programming in R and/or Python;
- Experience with computational method development and integrative analysis of large-scale datasets; experience with single-cell and spatial transcriptomics and/or functional-genomic data is an advantage;
- Affinity with machine learning and translational cancer research; experience with clinically annotated cohorts and large public datasets is an advantage;
- A proven ability to work independently and collaboratively in a multidisciplinary environment, with excellent communication skills in written and spoken English;
- A track record of scientific writing and peer-reviewed publication commensurate with career stage.
€45000 - €55000 monthly