Werken bij GenomescanESR (PhD) Position in the ‘TransPot’ Project on the Systems Biology of Therapy-resistant Prostate Cancer Location (Leiden- The Netherlands)Engelstalige vacaturetekst:
GenomeScan is seeking an Early Stage Researcher (ESR) in the Horizon 2020 Marie Sklodowska Curie project ‘Transpot’. This is a position for three years (36 months). The planned starting date for the position is June 1st, 2017.
The Translational Research Network for Prostate Cancer (TransPot) is a pan-European academic/private/clinical sector research training network focused on Translational Cancer Research, Cancer Cell Biology and Applied Systems Biology/ Systems Medicine. TransPot will integrate the leading research scientists and laboratories in Europe with an interest in these research fields and train 10 early stage researchers (ESRs). TransPot will incorporate the latest multi-disciplinary research technologies to understand lethal prostate cancer (PC). The TransPot consortium will offer an innovative research training program to its ESRs to ensure that they can effectively operate in today’s multi-disciplinary scientific world. This will include both research (e.g. target validation and drug discovery; biomarker discovery and validation) and transferable skill sets (e.g. cross species onco- omics analysis; novel preclinical (culture/in vivo) models). Because of this unique training program, the ESRs will develop into the next generation of multi-disciplinary scientists with skills that are in great demand for both today’s academic and non-academic sectors. The TransPot project is coordinated by the University of Glasgow (UK), and includes 7 academic centers and 3 commercial entities from 6 European countries.
GenomeScan www.genomescan.nl is a young enterprise that originated from the long and intensive collaboration between the Leiden University Medical Center (LUMC) and ServiceXS B.V. ServiceXS was founded in 2002 by five young pioneers in Genetics. Today, GenomeScan has extensive technical expertise and access to the latest technologies available for Next Generation Sequencing analysis. Our validated protocols for analysis of small RNAs have been used to profile all known human miRNAs and to discover novel small RNAs of various lengths, coding and non-coding, that may be used as biomarkers for the classification of human disease stages.Job Description
The ESR at GenomeScan will focus on the Bio-IT of next-generation sequencing data and systems biology (systems medicine) of incurable prostate cancer by performing multi-omics analyses and biomarker validation. The major goal will be to generate a systems biology understanding, based on a cross-species omics approach and human clinical materials. Tasks include:Extraction of miRNA from tissue, urine and blood samples, and to carry out global miRNA analysis using Next-Generation-Sequencing;Statistical analysis of miRNA alterations to predict miRNA targets using specialized software (e.g. Ingenuity pathway analysis);Correlation of tissue, urine and blood miRNA data with other –omics data collected within the network (transcriptomics, proteomics);Validation of selected miRNAs, investigation of their effects on target mRNAs and their interactions with both mRNAs and proteins;Cross-species onco-omics, informatics, and mathematical modelling of multiple datasets in parallel;Data integration and cross-evaluation with the experimental in vitro model systems;Publication of findings in high-ranking peer-reviewed journals.The ESR will be based at GenomeScan in Leiden and work in a multidisciplinary team of molecular biologists and bio-informaticians under supervision of Dr. Zoraide Granchi.
The ESR will be enrolled in the PhD program at the University of Glasgow (UK) under the supervision of professor Hing Leung (http://www.gla.ac.uk/).
Coherently with the Marie Curie Training Program the ESR will be involved in many different aspects of research, and will work closely together with some of the other ESR’s within the network.
Furthermore, the ESR will take part in training programs and workshops, as well as secondments at several of the other institutions that form the network.Requirements
To be eligible, the candidate must fulfill each of the following criteria at the time of recruitment:The candidate must have a Master’s Degree in Life Sciences with interest to gain a PhD in the field of cancer genetics and systems biology;He/she is enthusiastic about pursuing a research project within a commercial organization;The candidate should have an excellent command of English;Applicants should not have resided or performed their main activity (work, studies, etc) in the Netherlands for more than 12 months in the 3-year period immediately prior to the start date of the research;Applicants for the ESR positions should be in the first 4 years (full-time equivalent) of their research careers and not yet have been awarded a doctorate. This 4-year period is measured from the date of obtaining the degree which would formally entitle to embark on a doctorate;The candidate needs to be willing to relocate to the Netherlands (Leiden/ The Hague).Benefits
The ESR will be contractually employed on a temporary basis by GenomeScan and covered under the social security scheme.He or she will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Sklodowska Curie Actions-ITN general conditions (http://ec.europa.eu/assets/eac/msca/documents/documentation/publications/msca-fellows-information-package_en.pdf).Application procedure
Candidates are invited to submit all application documents in English to Mrs. Fanny Broekhuizen – Klik op de solliciteer-button om te solliciteren –
Please include the following documents in your application:A letter stating your motivation to apply for this positionCVList of publicationsTranscript of gradesContact information of at least two references The deadline for submitting an application is March 31st 2017. For further info on the position, please contact Dr. Zoraide Granchi – Klik op de solliciteer-button om te solliciteren –Please ensure that you qualify before applying, as ineligible candidates cannot be considered.