Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, displaying reproductive and metabolic dysfunction. Although the etiology of PCOS is still poorly understood, androgens are considered to play a major role. In addition, anti-Müllerian hormone (AMH) has been implicated. One of the goals of our laboratory is to gain more insight into the fundamental mechanisms contributing to the phenotypes of PCOS.
The current postdoctoral project aims at unraveling the mechanisms by which AMH and androgens contribute to the development and severity of PCOS-related phenotypes. We will use genetic mouse models and state-of-the art molecular tools to determine effects on metabolic tissue function, insulin resistance and reproductive function. We aspire to translate our findings to the human disease.Work environment
The Department of Internal Medicine is a large department with several research groups. Within the section Endocrinology, the research group “Metabolism and Reproduction” focuses on aspects of sex differences in metabolism in health and disease. We approach our research questions using physiological and cellular techniques, both in animal models and in humans. An important principle that guides our efforts is the possibility to apply our findings in the clinic and, vice versa, paying attention to questions that arise in the clinic when treating patients.
The candidate will be a member of a team that consists of PhD students, basic scientists and clinical scientists. Part of this project will be performed within an international collaboration.Qualifications and skills
The right candidate for this position will be a highly motivated and career-oriented PhD graduate with less than five year experience as post-doctoral fellow. The candidate has a strong background and track record in metabolic and reproductive biology.
Furthermore the following skills and qualifications are required:
• Demonstrated track record in basic/translational research, with evidence of ability to publish in peer-reviewed journals as first author;
• Strong background in cell culture and molecular biology;
• Experience with planning and executing mouse studies (art.9 certified);
• Excellent oral and written communication skills in Dutch and/or (academic) English;
• Able to work independently and as team-player in a multidisciplinary team.
Before you apply please check our conditions for employment.Terms of employment
The full-time position is offered for one year initially, with the option of extension after a yearly evaluation. The gross monthly salary amounts a maximum of € 4.481,- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).Information and application
For more information about this position, please contact Dr. Jenny Visser, Head of Metabolism and Reproduction lab, phone number: +31 (0)10 703 05 33 or e-mail: firstname.lastname@example.org. For queries regarding your application, please contact Jerry Chandansingh, recruiter, phone number: +31 (0)6 500 310 06.
If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.
No agencies please.
Uren per week: 36 hours