Alterations in DNA repair pathways are common in sporadic as well as hereditary cancers, and tailored therapeutic approaches have been developed to target specific vulnerabilities in cancers that display DNA repair defects. DNA repair during sexual reproduction is altered via the action of several meiosis-specific DNA repair factors. In several cancers, aberrant re-expression of these genes has been observed, but the functional significance and consequence of these events on DNA repair fidelity and dynamics remains poorly understood. In addition, it remains unexplored whether the aberrant expression of meiotic genes leads to specific genetic vulnerabilities in certain cancers.
The aim of this PhD research project is to investigate the functional effects of selected meiosis-specific DNA repair factors on DNA repair dynamics in cancer cells. To do so, we aim to develop state-of-the-art methodologies – centered around cell biological, genetic and bioinformatic approaches – to study how these factors might be exploited by cancer cells in order to alter DNA repair and genome stability. We will employ genome-wide CRISPR/Cas9-based screening in order to reveal genetic networks centered around selected meiotic factors. Such approaches are expected to provide novel insights into the etiology of human cancers, while also holding promise for the development of novel biomarkers and/or therapeutic avenues for diagnosis and treatment of human cancer.Your profile
We are looking for a passionate graduate candidate with a master’s degree in molecular / biomolecular sciences, or biochemistry / biology / medical biology with a strong interest in molecular mechanisms of genome stability and cancer.
To perform this project we are looking for a PhD candidate with:
You will work in the Vader group located in the Oncogenetics section of the Human Genetics department, Amsterdam UMC, location VUmc. The Oncogenetics section is part of the Cancer Center Amsterdam (CCA) where groundbreaking research is carried out on cancer genes and hereditary cancer. This section has specialized in the use of CRISPR-Cas9 technology and also houses the Amsterdam UMC CRISPR Expertise Center.
Working at Amsterdam UMC means working in an inspiring and professional environment where developing one`s talents and academic skills are encouraged. We offer you ample opportunity for development, deepening and broadening, additional training, and a place to grow!We offer
Salary Scale PHD: 2495 tot 3196 euro gross when employed full-time (depending on qualifications and experience).
The monthly wage will increase yearly to the maximum salary in the fourth year of 3,196 € gross per month.
In addition, we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8.0% holiday pay.
– The opportunity to follow further training and development.
– Pension is accrued at the ABP. VUmc contributes a large part of the premium (70%).
– In addition to excellent accessibility by public transport, we reimburse 75% of your OV travel costs (commuting costs).
We offer an initial contract for 12 months that will be extended (after evaluation) for another 36 months.
For more information about our employment conditions, please visit our website.
For Dutch citizens it is mandatory to provide a VOG (Verklaring Omtrent Gedrag). Foreign citizens need to provide comparable police clearing certificates.Additional information
The desired starting date for the position is as soon as possible, but can be discussed in consultation.Information and application
Don’t hesitate to call us!
If you’re interested about this position, you can contact Dr. ir. Gerben Vader, via telephone number 020-4449986.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at 020-4445635.
You can apply till 8 August 2021 by using the apply button.
Acquisition based on this vacancy is not appreciated.Herinner mijSolliciteren