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This vacancy is posted as part of RegMedXB, which stands for “Regenerative Medicine Crossing Borders”. RegMedXB is a virtual institute composed of universities, health foundations, governments and private companies in the Netherlands and Belgium. The partners work together to tackle some of the greatest challenges in regenerative medicine, while building a community of researchers and companies to realize health and economic benefits. The RegMedXB Cardiac Moonshot program aims at developing innovative strategies to regenerate the tissues of the heart, including the myocardium, heart valves and blood vessels.
The current project concentrates on developing cartilage organoids from iPSCs in suspension culture and their use in hyaline neo-cartilage formation. For this you will investigate the mechanobiological induction and culture conditions of induced chondrocytes and organoid self-assembly using advanced culture platforms and characterization assays. The produced organoids will be combined with innovative relaxing hydrogels and in a bi-directional loaded ex vivo osteochondral culture bioreactor to investigate their mechanism for formation into neo-cartilage.
If you are fascinated by the engineering aspects of regenerative medicine and eager to develop innovate models and strategies that will advance cartilage regeneration, we invite you to join us in this challenge. You will collaborate intensively with our partners in the RegMed-XB OA Moonshot consortium, in particular with the University Medical Centers in Leiden and Utrecht, as well as commercial partners, on iPSC induction, in vitro organoid self-assembly, and ex vivo load stimulated tissue engineering.Functie-eisen
Do you recognize yourself in this profile and would you like to know more? Please contact
prof.dr. Keita Ito, k.ito[at]tue.nl.
Information about the RegMedXB program can be found on: www.regmedxb.com
Information about the Biomedical Engineering department can be found at: https://www.tue.nl/en/our-university/departments/biomedical-engineering/
Information about the Orthopaedic Biomechanics group can be found at: https://www.tue.nl/en/research/research-groups/orthopaedic-biomechanics/
For information about terms of employment, please contact Sascha Sanchez, HR advisor, s.j.m.g.sanchez.van.oort[at]tue.nl or HRServices.Gemini[at]tue.nl
Please visit www.tue.nl/jobs to find out more about working at TU/e!
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Screening will continue until the position has been filled.
About Eindhoven University of Technology (TU/e)
TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.
The Department of Biomedical Engineering (BME) offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.
The research will be mainly conducted within the Soft Tissue Engineering and Mechanobiology (STEM) group in the Department of Biomedical Engineering.
The OPB group, headed by prof.dr. K. Ito, combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. They cover diverse topics in bone, intervertebral disc and tendons/ligaments, as well as articular cartilage. The group is well known for their multidisciplinary approach combining tissue mechanics, mechanobiology, tissue and biomaterial mechanics, ex vivo bioreactor platforms and computational models to optimize tissue conditions for regenerative engineering. The group houses the Cell and Tissue Engineering laboratory, a shared research infrastructure operating at the international forefront of the engineering of living, load-bearing tissues.Solliciteer nuStuur door