Understanding how the immune system interacts with cancer is crucial for effective cancer immunotherapy. Clinical and epidemiological data suggests a protective effect of vitiligo against non-melanoma skin cancer. In this PhD project you will explore this relation on multiple levels, in the field of cancer biology and immunology. You will test the ability and explore the mechanisms through which vitiligo-based immune responses target basal cell carcinoma and squamous carcinoma. This will be done in vitro using patient-derived immune and tumor cells, as well as in vivo using relevant mouse models. To better understand therapy response and determine potential tumor antigens you will perform expression analysis using Opal multiplex immunohistochemistry and RNAseq on tumor samples. In parallel, as part of an ongoing line of research in the lab, you will also have the opportunity to analyze the synergy of monobenzone-imiquimod immunotherapy in vivo in a pre-clinical melanoma model.What we expect from you
We are looking for a highly motivated and enthusiastic PhD student with a strong interest in immunology and oncology. You have a master degree in a relevant study and received excellent scientific training in the field of immunology, oncology or a related field. You have strong affinity with animal (mouse) work, you are article 9 certified (completed the course Laboratory Animal Science “Proefdierkunde”) and already have hands-on animal experience. You have outstanding experimental research skills, are well organized and results-driven, and have a strong team spirit, but you can also function independently. You have also good written and spoken English language skills.Where you are going to work
The Laboratory of Expermental Dermatology (LED) of the department of Dermatology is specialized in translational and immunological research on pigment cell disorders of the skin, including vitiligo and melanoma, and inflammatory skin diseases. The department of Dermatology of the Amsterdam UMC is the NFU acknowledged center of expertise for pigment cell disorders, which creates an inspiring environment of clinical and scientific expertise for translational research. LED is part of the Cancer Center Amsterdam and the Amsterdam institute for Infection and Immunity (AII) which both offer an excellent scientific and social environment in the field of cancer immunology. You will also participate in the Oncology Graduate School Amsterdam (OOA), a joint Graduate School of AMC, NKI-AvL and VUmc.What we offer you
We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.
For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/Let’s meet
If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact Rosalie Luiten (Hoofd Laboratorium Experimentele dermatologie), via firstname.lastname@example.org.
We look forward to meeting you!