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Originele vacaturetekst

PhD Student (promovendus) Atrial Fibrillation Research Group

What you are going to do

Atrial fibrillation (AF) is the most common cardiac arrhythmia and poses an increasing burden on patients’ health, well-being and healthcare budgets. The AF Research Group of the Amsterdam UMC combines clinical and translational research. We combine clinical knowledge with life science technology to understand the pathophysiologic mechanism of atrial fibrillation and to discover new biomarkers and targets for therapy.

An important subject of investigation is how the atrium remodels to facilitate occurrence and perpetuation of the arrhythmia. We are particularly interested in how the arrhythmogenic substrate in the atrium develops, both before the emerging of the arrhythmia, and during its progression to persistent and permanent forms. For that, a large biobank containing blood, tissue and clinical characteristics and follow-up of >700 patients with and without AF is available, that is closely intertwined with our Thoracoscopic AF ablation program.

This research project will focus on the determinants of arrhythmogenic substrate development. The candidate will work on molecular biological techniques as well as on clinical projects to uncover how specific arrhythmogenic substrates relate to clinical outcome of AF therapy, and how the development of the substrate can be modified and reversed. During the appointment, the candidate will perform fundamental, bioinformatics and clinical research and write several scientific articles that will together compose a PhD thesis. .

We offer:

  • A position as PhD student (promovendus) in the Heart Center, department of Cardiology.
  • A stimulating, diverse and internationally oriented research environment. The Atrial Fibrillation Research Group (Head: Prof. Dr. J.R. de Groot) takes part in the esteemed Clinical and Experimental Cardiology department of the Amsterdam UMC, location AMC in Amsterdam, which has a long track record of research in cardiology, electrophysiology and genetics. The AF Research Group focuses on clinical, basic and translational research of AF.
  • An opportunity to work in collaboration with basic scientists, cardiologists, surgeons and translational scientists. Within that collaboration you will have the opportunity to grow, take initiative and set out directions.
  • An opportunity to function within the internationally renowned Thoracoscopic AF ablation program.
  • A teaching role in the projects of BSc/MSc students.
  • The city of Amsterdam is a metropolis with a diverse and open multicultural population.
  • An initial 1-year appointment in accordance with CAO UMC 2018-2020, (salary depending on relevant experience), with the opportunity of extension.
What we expect from you

We are looking for an enthousiastic physician researcher with:

  • A completed MD (or MSc in Medicine, Biology) or other relevant Life Sciences.
  • Ambition to perform translational projects in combination with clinical research.
  • Strong motivation to investigate the field of AF fundamental mechanisms.
  • Excellent communication skills.
  • Proactivity and independence. The ambition to set up new experiments and research projects.
Where you are going to work

You will work in a team with several (physician) researchers. Together we manage the ongoing clinical trials. Everyone has his own responsibilities and tasks and we help each other when needed. There are weekly meetings in which we discuss our plans, progress and results.

What we offer you

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

  • The maximum gross monthly salary based on a 36-hour work week is € 4.481,- (scale 10 CAO UMC).
  • The base salary does not include holiday pay (8%) and a year-end bonus (8.3%).
  • We offer a contract for 12 months, with the prospect of extending the contract upon good performance.
  • In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
  • Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see

Let’s meet

If you would like to apply directly, please use the ‘apply’ button on this page.
If you would like more information, please feel free to contact prof. dr. Joris deGroot (Cardioloog), via

We look forward to meeting you!

Because of the coronavirus, healthcare is our main focus now in Amsterdam UMC. This means that it will probably take longer before we give you feedback on your application, or schedule job interviews. Thank you for your understanding!

Uren per week: 36 hours per week