TU Delft

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Originele vacaturetekst

Postdoc Sub-cellular biopsy; a key technology to gather fundamental knowledge for effective cancer therapy

Faculty Mechanical, Maritime and Materials Engineering

The 3mE Faculty trains committed engineering students, PhD candidates and post-doctoral researchers in groundbreaking scientific research in the fields of mechanical, maritime and materials engineering. 3mE is the epitome of a dynamic, innovative faculty, with a European scope that contributes demonstrable economic and social benefits.

The Department of Precision and Microsystems Engineering (PME) carries out research and provides education in the field of high-tech systems and scientific instrumentation. We aim to solve fundamental questions in engineering science to advance the performance of precision systems and devices as well as their design. Our specific mission is to merge mechanical engineering concepts with micro and nanoscience. We deliver skilled professionals and contribute knowledge to support leadership of the high-tech systems industry.

Functie omschrijving

We are looking for a self-motivated postdoc with a strong interest to work in a flagship multidisciplinary project between Technical University Delft and Erasmus Medical Centre on a sub-cellular biopsy (SCSY), supported by the Convergence initiative.

The initiative stimulates collaboration between both the technical institute (TU Delft) and the medical institute (Erasmus MC) with the aim to address health related challenges.

The goal of this (SCSY) project is to understand the DNA repair mechanism in radiation therapy. The approach will be to enter the nucleus of cells using microfluidic atomic force microscopy cantilever and extract temporally formed organelles involved in repair of DNA damage.

The extracted sample will be subsequently analysed by cryo-electron microscopy and mass spectrometry.

The postdoc will collaborate with a peer-postdoc to be appointed in parallel at the Erasmus MC on the same project. The postdoc at Erasmus MC will do genomic engineering of appropriate cell lines expressing fluorescent DNA repair proteins in different genetic backgrounds to dissect distinct steps in DNA repair. The project will be executed in a multi-disciplinary team from Erasmus MC and TU Delft consisting of experts in Molecular Genetics, Cell Biology, (Bio)mechanical Engineering, Microfabrication, Instrumentation, Electron Microscopy and Mass Spectrometry.

Functie eisen

PhD in Physics/Applied Physics/Mechanical Engineering/Biomechanical Engineering/Micro-Nanotechnology/Biophysics

Skills desired:

• Atomic force microscopy

• Microfluidics

• Microfabrication

• Biomechanical characterization

• Implementing measurement schemes for micro-nanoscale devices

• Characterization methods like SEM, TEM, mass spectrometry

• Collaborative and team player


The candidate should have a deep interest in the convergence of health sciences, physical sciences, and engineering to foster individual health and keep the healthcare system sustainable. The candidate will work closely with the supervisors, principal investigators and collaborating investigators of the Convergence initiative to conduct high calibre research. The candidate is also encouraged to initiate and lead collaborative work with other postdocs within the Convergence for health(care) initiative. Salary will be commensurate with qualification and experience.


TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

Informeren en solliciteren

For more information about the positions, you can contact Dr. M.K. Ghatkesar, Assistant Professor m.k.ghatkesar@tudelft.nl.

For information about the selection procedure, please contact Irina Bruckner, HR advisor at application-3me@tudelft.nl.

To apply send at your earliest convenience to application-3mE@tudelft.nl your CV, motivation letter and the contact details of 2 references, referring to the vacancy number.

Recruitment will take place until the vacancy has been filled.

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.

Uren per week: 38.0 uur per week

Salaris: € 3.389,- tot € 4.274,- per maand